Although in the past century mortality in West Germany decreased similarly as in other
Western nations, these changes were less pronounced in East Germany. 1, 2 After German …

The exploitation of recombinant DNA technology to engineer expression systems for
heterologous proteins represented a major task within the field of biotechnology during the last …

The tannase‐encoding Arxula adeninivorans gene ATAN1 was isolated from genomic DNA
by PCR, using as primers oligonucleotide sequences derived from peptides obtained after …

The methylotrophic yeast Hansenula polymorpha is a recognised model system for
investigation of peroxisomal function, special metabolic pathways like methanol metabolism, of …

Background Chimeric virus-like particles (VLP) allow the display of foreign antigens on their
surface and have proved valuable in the development of safe subunit vaccines or drug …

Vascularization and tumor cell proliferation were analyzed in 33 resected human squamous
cell carcinomas of the esophagus using the endothelium-specific antibody BW 200 and the …

We have introduced the glucoamylase gene (GAM1) from Schwanniomyces occidentalis
into the genome of the methylo-trophic yeast Hansenula polymorpha to study the potential of …

A vaccine to prevent hepatitis C virus (HCV) infection is urgently needed for use alongside
direct-acting antiviral drugs to achieve elimination targets. We have previously shown that a …

Combining ease of genetic manipulation and fermentation with the ability to secrete and to
glycosylate proteins in the basic eukaryotic manner, Arxula adeninivorans provides an …

The development of effective malaria vaccines remains a global health priority. Currently, the
most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. …