Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving
to be effective at restoring T cell-mediated immune responses that can lead to marked and …

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from
embryonic precursors that seed the tissues prior to birth to generate a self-renewing population…

Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but
precise interspecies correlation is currently incomplete. Here, we showed that murine lung …

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the
periphery is critical for the initiation of CD8 + T cell responses. Several DC subsets are described …

Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic
potential. Multiple DC subsets have been described, and it remains challenging to align them …

The increasing volume of ChIP-chip and ChIP-seq data being generated creates a challenge
for standard, integrative and reproducible bioinformatics data analysis platforms. We …

INTRODUCTION Resident tissue macrophages (RTMs) are a heterogeneous population of
immune cells occupying multiple tissue niches and exhibiting microenvironment-specific …

Microglia are embryonically seeded macrophages that contribute to brain development,
homeostasis, and pathologies. It is thus essential to decipher how microglial properties are …

The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within the …

Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct
lineages: the CD8α + (CD103 + ) cDC1 lineage, and the CD11b + cDC2 lineage. cDCs arise …