Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Objective To identify single-nucleotide polymorphisms (SNPs) associated with risk and age
at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. …

The paper describes numerical procedures, based on the method of dynamic relaxation with
kinetic damping, for the form finding, analysis and fabrication patterning of wide-span cable …

Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40% of …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Genome-wide association studies (GWAS) testing several hundred thousand SNPs have
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number …

Over the past few years, large investments have been made in genome-wide association
studies (GWAS) with the expectation that some of these studies would lead to the identification …

Objective The purpose of this study was to identify genetic variants underlying the considerable
individual differences in response to antidepressant treatment. The authors performed a …

Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …