Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

IN Western Europe and the United States approximately 1 in 12 women develop breast cancer.
A small proportion of breast cancer cases, in particular those arising at a young age, are …

All cancers arise as a result of changes that have occurred in the DNA sequence of the
genomes of cancer cells. Over the past quarter of a century much has been learnt about these …

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development, …

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation …

A central aim of cancer research has been to identify the mutated genes that are causally
implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …