Despite preclinical studies demonstrating the functional benefit of transplanting human
pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the ability of …

Rationale: The developing heart requires both mechanical load and vascularization to
reach its proper size, yet the regulation of human heart growth by these processes is poorly …

Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs)
have great potential as a cell source for therapeutic applications such as regenerative …

Background: Tissue engineering enables the generation of functional human cardiac tissue
with cells derived in vitro in combination with biocompatible materials. Human-induced …

The heart either hypertrophies or dilates in response to familial mutations in genes encoding
sarcomeric proteins, which are responsible for contraction and pumping. These mutations …

Understanding the phenotypic development of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy, …

Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the
development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing …

The epicardium and its derivatives provide trophic and structural support for the developing
and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived …

During neonatal development, there is an increase in myocardial stiffness that coincides
with an increase in the contractility of the heart. In vitro assays have shown that substrate …

How does neural activity drive muscles to produce behavior? The recent development of
genetic lines in Hydra that allow complete calcium imaging of both neuronal and muscle activity…