The incidence of chronic pain is estimated to be 20–25% worldwide. Few patients with chronic
pain obtain complete relief from the drugs that are currently available, and more than half …

Sensitization of primary afferent neurons underlies much of the pain and tenderness associated
with tissue injury and inflammation. The increase in excitability is caused by chemical …

DOI of original article: 10.1016/j. vaccine. 2007.02. 063. Disclaimer: The findings, opinions,
and assertions contained in this consensus document are those of the individual scientific …

We report evidence for a contribution of tetrodotoxin-resistant sodium current (TTX-R I Na ) to
prostaglandin E 2 (PGE 2 )-induced hyperalgesia. Behavioral experiments were performed …

In September 2006, members of the Sex, Gender and Pain Special Interest Group of the
International Association for the Study of Pain met to discuss the following: (1) what is known …

▪ Abstract Nociceptors are the first cells in the series of neurons that lead to the sensation of
pain. The essential functions of nociceptors—transducing noxious stimuli into …

To define the prevalence of total coronary occlusion in the hours after transmural myocardial
infarction, we used coronary arteriography to study the degree of coronary obstruction in …

Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to peripheral
nerves. Such pain has been hypothesized to be the result of an aberrant expression and …

The underlying mechanisms of neuropathic pain are poorly understood, and existing
treatments are mostly ineffective. We recently demonstrated that antisense mediated “knock-down” …

A tetrodotoxin-resistant voltage-gated Na + current (TTX-R I Na ) appears to be the current
primarily responsible for action potential generation in the cell body and terminals of …