Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development. Here…

Existing human genome assemblies have almost entirely excluded repetitive sequences
within and near centromeres, limiting our understanding of their organization, evolution, and …

Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200
million base pairs of sequence, corrects thousands of structural errors, and unlocks the most …

The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has resolved
complex regions of the genome, including repetitive and homologous regions. Here, we …

The mammalian sperm genome is thought to lack substantial information for the regulation of
future expression after fertilization. Here, we show that most promoters in mouse sperm are …

Lamins are structural components of the nuclear lamina (NL) that regulate genome organization
and gene expression, but the mechanism remains unclear. Using Hi-C, we show that …

Background Hi-C is currently the most widely used assay to investigate the 3D organization
of the genome and to study its role in gene regulation, DNA replication, and disease. …

The chromatin interaction assays 5C and HiC have advanced our understanding of genomic
spatial organization, but analysis approaches for these data are limited by usability and …

Homologous chromosomes colocalize to regulate gene expression in processes including
genomic imprinting, X-inactivation, and transvection. In Drosophila, homologous …