The shapes of eukaryotic cells and ultimately the organisms that they form are defined by
cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of …

How physical force is sensed by cells and transduced into cellular signaling pathways is
poorly understood. Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) in a …

Although the shapes of organisms are encoded in their genome, the developmental processes
that lead to the final form of vertebrates involve a constant feedback between dynamic …

Cell migration relies upon forces generated by the cell. Recent studies have provided new
insights into the processes by which cells generate and regulate the forces applied to …

Axoplasm from the squid giant axon contains a soluble protein translocator that induces
movement of microtubules on glass, latex beads on microtubules, and axoplasmic organelles on …

We propose that membranes whose proteins and polar lipids are distributed asymmetrically
in the two halves of the membrane bilayer can act as bilayer couples, ie, the two halves can …

The molecular mechanism by which a mechanical stimulus is translated into a chemical
response in biological systems is still unclear. We show that mechanical stretching of single …

To move forward, migrating cells must generate traction forces through surface receptors
bound to extracellular matrix molecules coupled to a rigid structure. We investigated whether …

Analysis of the trajectories of small particles at high spatial and temporal resolution using
video enhanced contrast microscopy provides a powerful approach to characterizing the …

To adhere and migrate, cells must be capable of applying cytoskeletal force to the extracellular
matrix (ECM) through integrin receptors. However, it is unclear if connections between …