The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of cellular
protective and maintenance functions. The most thoroughly described of these proteins, …

A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping
fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and …

The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …

10.7554/eLife.07836.001 In Caenorhabditis elegans, ablation of germline stem cells (GSCs)
extends lifespan, but also increases fat accumulation and alters lipid metabolism, raising …

Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal cells, and
lamellocytes based on the expression of a few marker genes and cell morphologies, which …

Chronic inflammation predisposes to aging-associated disease, but it is unknown whether
immunity regulation might be important for extending healthy lifespan. Here we show that in C…

Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here, we …

Xenobiotic metabolism has been proposed to play a role in modulating the rate of aging.
Xenobiotic metabolizing enzymes (XME) are expressed at higher levels in calorically restricted …

Individually, dysfunction of both the endoplasmic reticulum (ER) and mitochondria has been
linked to aging, but how communication between these organelles might be targeted to …

Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some
lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), …