The Blue Obelisk—interoperability in chemical informatics

R Guha, MT Howard, GR Hutchison… - Journal of chemical …, 2006 - ACS Publications
The Blue Obelisk Movement ( http://www.blueobelisk.org/ ) is the name used by a diverse
Internet group promoting reusable chemistry via open source software development, …

Mutational spectrum of DMD mutations in dystrophinopathy patients: application of modern diagnostic techniques to a large cohort

…, P Soltanzadeh, E Gappmaier, MT Howard… - Human …, 2009 - Wiley Online Library
Mutations in the DMD gene, encoding the dystrophin protein, are responsible for the
dystrophinopathies Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD), and …

Sequence specificity of aminoglycoside‐induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy

MT Howard, BH Shirts, LM Petros… - Annals of Neurology …, 2000 - Wiley Online Library
As a result of their ability to induce translational readthrough of stop codons, the aminoglycoside
antibiotics are currently being tested for efficacy in the treatment of Duchenne muscular …

[HTML][HTML] Programmed ribosomal frameshifting in decoding the SARS-CoV genome

…, CB Anderson, RF Gesteland, JF Atkins, MT Howard - Virology, 2005 - Elsevier
Programmed ribosomal frameshifting is an essential mechanism used for the expression of
orf1b in coronaviruses. Comparative analysis of the frameshift region reveals a universal shift …

[HTML][HTML] Selenoprotein gene nomenclature

…, A Holmgren, RJ Hondal, MT Howard… - Journal of Biological …, 2016 - ASBMB
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins).
These proteins are involved in a variety of functions, most notably redox …

LTBP4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy

…, KJ Swoboda, E Gappmaier, MT Howard… - Annals of …, 2013 - Wiley Online Library
Objective Duchenne muscular dystrophy (DMD) displays a clinical range that is not fully
explained by the primary DMD mutations. Ltbp4, encoding latent transforming growth factor‐β …

Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

…, JJ Abramson, MT Howard… - Proceedings of the …, 2008 - National Acad Sciences
Mutations affecting the seemingly unrelated gene products, SepN1, a selenoprotein of unknown
function, and RyR1, the major component of the ryanodine receptor intracellular calcium …

Clinical and genetic characterization of manifesting carriers of DMD mutations

…, E Gappmaier, LE Taylor, MT Howard… - Neuromuscular …, 2010 - Elsevier
Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly
in the absence of a family history of dystrophinopathy. We review the clinical and genetic …

Independent evolution of bitter-taste sensitivity in humans and chimpanzees

S Wooding, B Bufe, C Grassi, MT Howard, AC Stone… - Nature, 2006 - nature.com
It was reported over 65 years ago that chimpanzees, like humans, vary in taste sensitivity to
the bitter compound phenylthiocarbamide (PTC) 1 . This was suggested to be the result of a …

[PDF][PDF] Enterprise: A market-like task scheduler for distributed computing environments

TW Malone, RE Fikes, MT Howard - 1983 - dspace.mit.edu
This paper describes a system for sharing tasks among processors on a network of personal
computers and presents an analysis of the problem ofscheduling tasks on such a network. …