Background Tumorigenic breast cancer cells that express high levels of CD44 and low or
undetectable levels of CD24 (CD44 > /CD24 >/low ) may be resistant to chemotherapy and …

Some breast cancers have been shown to contain a small fraction of cells characterized by
CD44 + /CD24 −/low cell-surface antigen profile that have high tumor-initiating potential. In …

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase
metastasis 1 , 2 . This paradox may be resolved by vessel normalization 3 , which involves …

Breast cancer research is hampered by difficulties in obtaining and studying primary human
breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived xenografts …

Despite advances in the treatment of patients with early and metastatic breast cancer, mortality
remains high due to intrinsic or acquired resistance to therapy. Increased understanding …

Transmitochondrial cybrids and multiple OMICs approaches were used to understand
mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative …

Type I insulin-like growth factor receptor (IGF-IR) can transform mouse fibroblasts; however,
little is known about the transforming potential of IGF-IR in human fibroblasts or epithelial …

Purpose: Accumulating evidence supports the existence of breast cancer stem cells (BCSC),
which are characterized by their capacity to self-renew and divide indefinitely and …

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic and …