The repair of wounds is one of the most complex biological processes that occur during
human life. After an injury, multiple biological pathways immediately become activated and are …

In adults and children over two years of age, large cranial defects do not reossify successfully,
posing a substantial biomedical burden. The osteogenic potential of bone marrow stromal …

In the United States, chronic wounds affect 6.5 million patients. An estimated excess of US$25
billion is spent annually on treatment of chronic wounds and the burden is rapidly growing …

Recent studies have demonstrated that adipose-derived mesenchymal cells (AMCs) offer
great promise for cell-based therapies because of their ability to differentiate toward bone, …

Bone development occurs through a series of synchronous events that result in the formation
of the body scaffold. The repair potential of bone and its surrounding microenvironment — …

INTRODUCTION Skin wounds generally heal by scarring, a fibrotic process mediated by the
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three ways…

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked
to arrhythmia and sudden cardiac death. While the causes of HCM have been identified as …

Hypertrophic scars occur following cutaneous wounding and result in severe functional and
esthetic defects. The pathophysiology of this process remains unknown. Here, we …

… Bullard KM, Longaker MT, Lorenz HP (2003) Fetal wound healing: Current biology.
World J Surg 27: 54–61. … Longaker MT, Whitby DJ, Ferguson MW, Lorenz HP, Harrison …

Recent in situ hybridization studies had demonstrated a strong increase in vascular
endothelial growth factor (VEGF) mRNA expression in the hyperproliferative epithelium during …