Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is
increasing. Reliable and predictable synthetic methods for the preparation of these …

Substituted piperazines and morpholines are valuable structural motifs in biologically active
compounds, but are not easily prepared by contemporary cross-coupling approaches. In this …

Commercially available SnAP (stannyl amine protocol) reagents allow the transformation of
aldehydes and ketones into a variety of N‐unprotected heterocycles. By identifying new …

Catechol dehydroxylation is a central chemical transformation in the gut microbial
metabolism of plant- and host-derived small molecules. However, the molecular basis for this …

The Friedel–Crafts alkylation is commonly used in organic synthesis to form aryl–alkyl C−C
linkages. However, this reaction lacks the stereospecificity and regiocontrol of enzymatic …

The sustainable development in pharmaceutical industries relies on the selection and
integration of detailed, unified metrics and indicators. This is particularly important when …

SnAP-eX (tin amine protocol, exocyclic heteroatoms) reagents allow the single-step
transformation of aldehydes and ketones into 2,3-disubstituted pyrrolidines and piperidines …

Saturated N-heterocycles can be found with increasing frequency in bioactive molecules,
despite their limited commercial availability and challenging synthetic routes. A direct …

Maculalactone A (1) constitutes a promising antifouling agent, inhibiting the formation of
biofilms in marine and freshwater systems. In this study, we developed a new route, based on a …

SnAP (Sn (tin) amine protocol) hydrazine reagents and aldehydes undergo oxidative, copper
mediated coupling to form substituted 1,4,5‐oxadiazepanes and 1,2,5‐triazepanes. Unlike …