User profiles for Michael Urbanowski

Michael E. Urbanowski

The University of Massachusetts Medical School
Verified email at umassmed.edu
Cited by 797

Cavitary tuberculosis: the gateway of disease transmission

ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse, …

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

…, E Schurr, G Srikrishna, M Urbanowski… - The Lancet infectious …, 2018 - thelancet.com
Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances in …

Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

…, S Srivastava, A Chen, EW Tucker, ME Urbanowski… - Nature medicine, 2020 - nature.com
Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at
least 6 months of multidrug treatment to achieve cure 1 . However, the lack of reliable data on …

A systematic approach for developing bacteria-specific imaging tracers

…, VP DeMarco, MH Klunk, ME Urbanowski… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The modern patient is increasingly susceptible to bacterial infections including those due to
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-…

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

…, P Kumar, A Kumar, ME Urbanowski… - Proceedings of the …, 2019 - National Acad Sciences
Denileukin diftitox (DAB-IL-2, Ontak) is a diphtheria-toxin–based fusion protein that depletes
CD25-positive cells including regulatory T cells and has been approved for the treatment of …

[HTML][HTML] Tuberculosis care models for children and adolescents: a scoping review

…, KA Yuengling, ME Urbanowski… - Bulletin of the World …, 2022 - ncbi.nlm.nih.gov
Methods We conducted a scoping review to assess the impact of decentralized, integrated
and family-centred care on child and adolescent tuberculosis-related outcomes, describe …

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

…, B Prideaux, RM Savic, ME Urbanowski… - Science translational …, 2018 - science.org
In clinical trials of two rifamycin antibiotics (rifampin and rifapentine) for treating tuberculosis
(TB), patients with cavitary lung lesions did not appear to derive benefit from rifapentine. …

[HTML][HTML] The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas

…, S Xiao, S Chatterjee, M Urbanowski… - The Journal of …, 2021 - Am Soc Clin Investig
The mechanism by which only some individuals infected with Mycobacterium tuberculosis
develop necrotic granulomas with progressive disease while others form controlled …

[HTML][HTML] Pathogenesis and animal models of post-primary (bronchogenic) tuberculosis, a review

…, JK Actor, SA Hwang, A Khan, ME Urbanowski… - Pathogens, 2018 - mdpi.com
Urbanowski … Deepak Kaushal assisted with the primate studies and Michael E.
Urbanowski and Wiliam Bishai provided valuable assistance with the rabbit studies. …

Repetitive aerosol exposure promotes cavitary tuberculosis and enables screening for targeted inhibitors of extensive lung destruction

ME Urbanowski, EA Ihms, K Bigelow… - The Journal of …, 2018 - academic.oup.com
Background Cavitation is a serious consequence of tuberculosis. We tested the hypothesis
that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis …