User profiles for Michael Urbanowski
Michael E. UrbanowskiThe University of Massachusetts Medical School Verified email at umassmed.edu Cited by 797 |
Cavitary tuberculosis: the gateway of disease transmission
ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse, …
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse, …
Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives
Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances in …
thousands of years alongside modern human populations. Despite considerable advances in …
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions
Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at
least 6 months of multidrug treatment to achieve cure 1 . However, the lack of reliable data on …
least 6 months of multidrug treatment to achieve cure 1 . However, the lack of reliable data on …
A systematic approach for developing bacteria-specific imaging tracers
The modern patient is increasingly susceptible to bacterial infections including those due to
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-…
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-…
Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma
Denileukin diftitox (DAB-IL-2, Ontak) is a diphtheria-toxin–based fusion protein that depletes
CD25-positive cells including regulatory T cells and has been approved for the treatment of …
CD25-positive cells including regulatory T cells and has been approved for the treatment of …
[HTML][HTML] Tuberculosis care models for children and adolescents: a scoping review
…, KA Yuengling, ME Urbanowski… - Bulletin of the World …, 2022 - ncbi.nlm.nih.gov
Methods We conducted a scoping review to assess the impact of decentralized, integrated
and family-centred care on child and adolescent tuberculosis-related outcomes, describe …
and family-centred care on child and adolescent tuberculosis-related outcomes, describe …
Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data
In clinical trials of two rifamycin antibiotics (rifampin and rifapentine) for treating tuberculosis
(TB), patients with cavitary lung lesions did not appear to derive benefit from rifapentine. …
(TB), patients with cavitary lung lesions did not appear to derive benefit from rifapentine. …
[HTML][HTML] The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas
…, S Xiao, S Chatterjee, M Urbanowski… - The Journal of …, 2021 - Am Soc Clin Investig
The mechanism by which only some individuals infected with Mycobacterium tuberculosis
develop necrotic granulomas with progressive disease while others form controlled …
develop necrotic granulomas with progressive disease while others form controlled …
[HTML][HTML] Pathogenesis and animal models of post-primary (bronchogenic) tuberculosis, a review
… Urbanowski … Deepak Kaushal assisted with the primate studies and Michael E.
Urbanowski and Wiliam Bishai provided valuable assistance with the rabbit studies. …
Urbanowski and Wiliam Bishai provided valuable assistance with the rabbit studies. …
Repetitive aerosol exposure promotes cavitary tuberculosis and enables screening for targeted inhibitors of extensive lung destruction
ME Urbanowski, EA Ihms, K Bigelow… - The Journal of …, 2018 - academic.oup.com
Background Cavitation is a serious consequence of tuberculosis. We tested the hypothesis
that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis …
that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis …