Epigenetic processes have been suggested as key mechanisms in the etiology of
neurodevelopmental disorders. This systematic review summarizes the current evidence for an …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

We conducted a genome-wide association study for age at natural menopause in 2,979
European women and identified six SNPs in three loci associated with age at natural …

We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …

purpose. Uveal melanoma is a highly malignant disease with a mortality rate of 50% at 10 to
15 years. Previous studies have shown that chromosomal changes are associated with …

Attention deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric
disorder. In addition, early life environmental factors contribute to the occurrence of ADHD. …

Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have
implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-…

Single nucleotide polymorphism (SNP) data generated with microarray technologies have
been used to solve murder cases via investigative leads obtained from identifying relatives of …