The role of epigenetic modifications in neurodevelopmental disorders: A systematic review
Epigenetic processes have been suggested as key mechanisms in the etiology of
neurodevelopmental disorders. This systematic review summarizes the current evidence for an …
neurodevelopmental disorders. This systematic review summarizes the current evidence for an …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
…, J Van Rooij, L Stolk, L Broer, MMPJ Verbiest… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Disease variants alter transcription factor levels and methylation of their binding sites
…, J Bot, RC Slieker, PM Jhamai, M Verbiest… - Nature …, 2017 - nature.com
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …
experiments to understand their functional consequences 1 , 2 . Identification of expression …
[PDF][PDF] DNA methylation analysis identifies loci for blood pressure regulation
…, A Hofman, PM Jhamai, M Verbiest… - The American Journal of …, 2017 - cell.com
Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
Loci at chromosomes 13, 19 and 20 influence age at natural menopause
L Stolk, G Zhai, JBJ van Meurs, MMPJ Verbiest… - Nature …, 2009 - nature.com
We conducted a genome-wide association study for age at natural menopause in 2,979
European women and identified six SNPs in three loci associated with age at natural …
European women and identified six SNPs in three loci associated with age at natural …
[PDF][PDF] Improving phenotypic prediction by combining genetic and epigenetic associations
…, AG Uitterlinden, PM Jhamai, M Verbiest… - The American Journal of …, 2015 - cell.com
We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …
mass index (BMI) and height and whether they predict these phenotypes over and above …
[HTML][HTML] Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients
…, CC Klaver, ME van Til, MM Verbiest… - … & visual science, 2005 - iovs.arvojournals.org
purpose. Uveal melanoma is a highly malignant disease with a mortality rate of 50% at 10 to
15 years. Previous studies have shown that chromosomal changes are associated with …
15 years. Previous studies have shown that chromosomal changes are associated with …
[HTML][HTML] DNA methylation profiles at birth and child ADHD symptoms
…, MI Bouwland-Both, MMPJ Verbiest… - Journal of psychiatric …, 2014 - Elsevier
Attention deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric
disorder. In addition, early life environmental factors contribute to the occurrence of ADHD. …
disorder. In addition, early life environmental factors contribute to the occurrence of ADHD. …
[HTML][HTML] Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs
…, AG Uitterlinden, PM Jhamai, M Verbiest… - Journal of …, 2016 - Elsevier
Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have
implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-…
implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-…
[HTML][HTML] Impact of SNP microarray analysis of compromised DNA on kinship classification success in the context of investigative genetic genealogy
…, A Vidaki, P Arp, V Kalamara, MMPJ Verbiest… - Forensic Science …, 2022 - Elsevier
Single nucleotide polymorphism (SNP) data generated with microarray technologies have
been used to solve murder cases via investigative leads obtained from identifying relatives of …
been used to solve murder cases via investigative leads obtained from identifying relatives of …