The molecular control of self-renewal and differentiation of stem cells has remained enigmatic.
Transgenic loss-of-function and overexpression models now show that the dosage of glial …

To elucidate the contribution of dehydrins (DHNs) to freezing stress tolerance in Arabidopsis,
transgenic plants overexpressing multiple DHN genes were generated. Chimeric double …

Following homozygosity mapping in a single kindred, we identified nonsense and missense
mutations in MYO5B, encoding type Vb myosin motor protein, in individuals with microvillus …

The extracellular signal-regulated kinase (ERK) cascade regulates proliferation, differentiation,
and survival in multicellular organisms. Scaffold proteins regulate intracellular signaling …

Five endosomal sorting complexes required for transport (ESCRTs) mediate the degradation
of ubiquitinated membrane proteins via multivesicular bodies (MVBs) in lysosomes. ESCRT…

Caveolae are specialized compartments of the plasma membrane that are involved in signaling,
endocytosis, and cholesterol transport. Their formation requires the transport of caveolin…

Microvillus inclusion disease (MVID) is a disorder of intestinal epithelial differentiation
characterized by life-threatening intractable diarrhea. MVID can be diagnosed based on loss of …

The blood cell–specific kindlin-3 protein is required to activate leukocyte and platelet
integrins. In line with this function, mutations in the KINDLIN-3 gene in man cause …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling
and quality control functions. Lysosomes are not static and they respond dynamically to …

10.7554/eLife.31652.001 The ESCRT machinery mediates reverse membrane scission. By
quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III …