User profiles for Michael-C. Keogh
 | Michael Christopher KeoghEpiCypher Inc. Verified email at epicypher.com Cited by 8085 |
Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II
CR Rodriguez, EJ Cho, MC Keogh… - … and cellular biology, 2000 - Taylor & Francis
The cotranscriptional placement of the 7-methylguanosine cap on pre-mRNA is mediated
by recruitment of capping enzyme to the phosphorylated carboxy-terminal domain (CTD) of …
by recruitment of capping enzyme to the phosphorylated carboxy-terminal domain (CTD) of …
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible
for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active …
for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active …
[PDF][PDF] Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …
Nucleosome conformation dictates the histone code
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized ‘codes’ that are read by specialized …
has been proposed that these PTMs form localized ‘codes’ that are read by specialized …
A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells
…, K Novitzky, E McAnarney, MC Keogh… - Genome …, 2021 - genome.cshlp.org
Antibodies offer a powerful means to interrogate specific proteins in a complex milieu. However,
antibody availability and reliability can be problematic, whereas epitope tagging can be …
antibody availability and reliability can be problematic, whereas epitope tagging can be …
Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization
Nuclear DNA in the male gamete of sexually reproducing animals is organized as sperm
chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm …
chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm …
[HTML][HTML] Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies
…, S Lin, LM Britton, K Krajewski, MC Keogh… - Scientific reports, 2012 - nature.com
Antibodies specific for histone post-translational modifications (PTMs) have been central to
our understanding of chromatin biology. Here, we describe an unexpected and novel …
our understanding of chromatin biology. Here, we describe an unexpected and novel …
The dCypher approach to interrogate chromatin reader activity against posttranslational modification-defined histone peptides and nucleosomes
…, IK Popova, EN Weinzapfel, MC Keogh - Chromatin: Methods and …, 2022 - Springer
Bulk chromatin encompasses complex sets of histone posttranslational modifications (PTMs)
that recruit (or repel) the diverse reader domains of Chromatin-Associated Proteins (CAPs) …
that recruit (or repel) the diverse reader domains of Chromatin-Associated Proteins (CAPs) …
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer
Mutations in the PHIP/BRWD2 chromatin regulator cause the human neurodevelopmental
disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to cancer. …
disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to cancer. …
Divergent subunit interactions among fungal mRNA 5′-capping machineries
…, RTK Janoo, V Polodny, Y Takase, MC Keogh… - Eukaryotic …, 2002 - Am Soc Microbiol
The Saccharomyces cerevisiae mRNA capping enzyme consists of two subunits: an RNA 5′-triphosphatase
(RTPase) and GTP::mRNA guanylyltransferase (GTase). The GTase …
(RTPase) and GTP::mRNA guanylyltransferase (GTase). The GTase …