Chloride channels play important roles in the plasma membrane and in intracellular
organelles. Mice deficient for the ubiquitously expressed ClC-7 Cl − channel show severe …

Several plasma membrane chloride channels are well characterized, but much less is known
about the molecular identity and function of intracellular Cl − channels. ClC-3 is thought to …

Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant
form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been …

ClC‐7 is a chloride channel of late endosomes and lysosomes. In osteoclasts, it may cooperate
with H + ‐ATPases in acidifying the resorption lacuna. In mice and man, loss of ClC‐7 or …

Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …

β-Amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical
role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the …

Loss of folate receptor-α function is associated with cerebral folate transport deficiency and
childhood-onset neurodegeneration. To clarify the mechanism of cerebral folate transport at …

Oligomannosidic glycans play important roles in nervous system development and function.
By performing a phage display screening with oligomannose-specific antibodies, we …

The neuron-specific K + –Cl − cotransporter KCC2 extrudes Cl − and renders GABA and
glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-…