Drug discovery and development pipelines are long, complex and depend on numerous
factors. Machine learning (ML) approaches provide a set of tools that can improve discovery …

In biomedical research, it is often necessary to compare multiple data sets with different
distributions. The bar plot, or histogram, is typically used to compare data sets on the basis of …

The Open Targets Platform ( https://www.targetvalidation.org/ ) provides users with a queryable
knowledgebase and user interface to aid systematic target identification and prioritisation …

The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics,
drugs, animal models and scientific literature to score and rank target-disease associations for …

Invasive fungal infections are an important cause of human mortality and morbidity, particularly
for immunocompromised populations. However, there remains a paucity of antifungal …

Ribosomes are the protein synthesizing factories of the cell, polymerizing polypeptide chains
from their constituent amino acids. However, distinct combinations of amino acids, such as …

Resistance to widely used fungistatic drugs, particularly to the ergosterol biosynthesis inhibitor
fluconazole, threatens millions of immunocompromised patients susceptible to invasive …

The structure of genetic interaction networks predicts that, analogous to synthetic lethal
interactions between non-essential genes, combinations of compounds with latent activities may …

There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal
concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, …

This study provides a useful model for MITF-low melanomas and MITF-independent cell
populations that can be used to study the mechanisms that drive these tumors as well as identify …