Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) has shown
promising results in metastatic melanoma patients. Although objective response rates of …

A variety of species of bacteria are known to colonize human tumours 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8
, 9 , 10 – 11 , proliferate within them and modulate immune function, which ultimately affects …

Purpose: Adoptive cell transfer (ACT) using autologous tumor-infiltrating lymphocytes (TIL)
was reported to yield objective responses in about 50% of metastatic patients with melanoma. …

Autologous T cells transduced with CD19-directed chimeric antigen receptors have recently
been approved by several regulatory agencies for the treatment of relapsed and refractory …

The neurotransmitter dopamine on its own increased significantly TNFα and IL-10 secretion
by resting normal-human T-cells, and induced ∼5-fold elevation of the corresponding …

Autologous T cells engineered to express a chimeric antigen receptor (CAR) against the
CD19 antigen are in the frontline of contemporary hemato-oncology therapies, leading to high …

Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here,
we investigated mechanisms of response by profiling the proteome of clinical samples from …

Abstract Treatment of metastatic melanoma patients with adoptively transferred tumor
infiltrating lymphocytes (TIL) has developed into an effective therapy. Various studies reported …

T cells may encounter glutamate, the major excitatory neurotransmitter in the nervous system,
when patrolling the brain and in glutamate-rich peripheral organs. Moreover, glutamate …

There is strong evidence that both adoptive T cell transfer and T cell checkpoint blockade
can lead to regression of human melanoma. However, little data are available on the effect of …