Doublecortin, a stabilizer of microtubules
…, F Francis, S Grayer Wolf, M Caspi… - Human molecular …, 1999 - academic.oup.com
X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been
demonstrated that the doublecortin gene is implicated in this disorder. In order to study the …
demonstrated that the doublecortin gene is implicated in this disorder. In order to study the …
LIS1, CLIP-170's key to the dynein/dynactin pathway
FM Coquelle, M Caspi, FP Cordelières… - … and cellular biology, 2002 - Taylor & Francis
CLIP-170 is a plus-end tracking protein which may act as an anticatastrophe factor. It has
been proposed to mediate the association of dynein/dynactin to microtubule (MT) plus ends, …
been proposed to mediate the association of dynein/dynactin to microtubule (MT) plus ends, …
Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders
M Caspi, A Wittenstein, M Kazelnik… - Advanced drug delivery …, 2021 - Elsevier
The canonical Wnt pathway is one of the key cellular signaling cascades that regulates, via
the transcriptional co-activator β-catenin, numerous embryogenic developmental processes, …
the transcriptional co-activator β-catenin, numerous embryogenic developmental processes, …
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin
A Hay-Koren, M Caspi, A Zilberberg… - Molecular biology of …, 2011 - Am Soc Cell Biol
Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse
array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that …
array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that …
Doublecortin mutations cluster in evolutionarily conserved functional domains
T Sapir, D Horesh, M Caspi, R Atlas… - Human Molecular …, 2000 - academic.oup.com
Mutations in the X-linked gene doublecortin (DCX) result in lissencephaly in males or
subcortical laminar heterotopia (‘double cortex’) in females. Various types of mutation were …
subcortical laminar heterotopia (‘double cortex’) in females. Various types of mutation were …
Interaction between LIS1 and doublecortin, two lissencephaly gene products
M Caspi, R Atlas, A Kantor, T Sapir… - Human molecular …, 2000 - academic.oup.com
Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly. Here
we report that LIS1 and DCX interact physically both in vitro and in vivo.Epitope-tagged DCX …
we report that LIS1 and DCX interact physically both in vitro and in vivo.Epitope-tagged DCX …
[HTML][HTML] Aldolase positively regulates of the canonical Wnt signaling pathway
M Caspi, G Perry, N Skalka, S Meisel, A Firsow, M Amit… - Molecular cancer, 2014 - Springer
The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during
animal development. When over-activated, this signaling pathway is involved in cancer …
animal development. When over-activated, this signaling pathway is involved in cancer …
[HTML][HTML] 14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway
S Dovrat, M Caspi, A Zilberberg, L Lahav, A Firsow… - Molecular …, 2014 - Elsevier
Aberrant activation of the canonical Wnt signal transduction pathway is involved in a large
number of human diseases. β-catenin, the key effector protein of the canonical Wnt pathway, …
number of human diseases. β-catenin, the key effector protein of the canonical Wnt pathway, …
5‐Hydroxymethylcytosine as a clinical biomarker: Fluorescence‐based assay for high‐throughput epigenetic quantification in human tissues
…, Y Michaeli, N Gilat, P Magod, M Caspi… - … Journal of Cancer, 2020 - Wiley Online Library
Epigenetic transformations may provide early indicators for cancer and other disease.
Specifically, the amount of genomic 5‐hydroxymethylcytosine (5‐hmC) was shown to be globally …
Specifically, the amount of genomic 5‐hydroxymethylcytosine (5‐hmC) was shown to be globally …
[HTML][HTML] The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members
M Breitman, A Zilberberg, M Caspi… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Adenomatous polyposis coli (APC) is a multifunctional tumor suppressor protein that negatively
regulates the Wnt signaling pathway. The APC gene is ubiquitously expressed in various …
regulates the Wnt signaling pathway. The APC gene is ubiquitously expressed in various …