FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in
embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling …

Fibroblast growth factors (FGFs) deliver extracellular signals that govern many developmental
and regenerative processes, but the mechanisms regulating FGF signaling remain …

FGF1 and FGF2 bind to specific cell-surface tyrosine kinase receptors (FGFRs) and activate
intracellular signaling that leads to proliferation, migration or differentiation of many cell types…

Recently, FGFR1 was found to be overexpressed in osteosarcoma and represents an
important target for precision medicine. However, because targeted cancer therapy based on …

Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular
functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (…

Sustained activation of extracellular signal–regulated kinase (ERK) drives pathologies caused
by mutations in fibroblast growth factor receptors (FGFRs). We previously identified the …

Extracellular fibroblast growth factor 1 (FGF1) acts through cell surface tyrosine kinase
receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of …

Besides its classical mode of action through activation of specific receptors at the cell surface,
fibroblast growth factor 1 (FGF1) can also cross the cellular membrane and translocate into …

Therapeutic potential of human acidic fibroblast growth factor (FGF1) resulting from its
undeniable role in angiogenesis and wound healing processes is questioned due to its low …

Fibroblast growth factor receptors (FGFRs) have become an attractive target in cancer research
and therapy due to their implication in several cancers. Limitations of current treatment …