Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification, assortative …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …

Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …

Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes.
In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (…