SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through binding of …

Multicellular organisms evolved sophisticated defence systems to confer protection against
pathogens. An important characteristic of these immune systems is their ability to act both …

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …

Effective antiviral protection in multicellular organisms relies on both cell-autonomous and
systemic immunity. Systemic immunity mediates the spread of antiviral signals from infection …

Insect viruses have evolved strategies to control the host RNAi antiviral defense mechanism.
In nature, Drosophila melanogaster C virus (DCV) infection causes low mortality and …

The Aedes aegypti mosquito transmits arboviruses, including dengue, chikungunya, and
Zika virus. Understanding the mechanisms underlying mosquito immunity could provide new …

The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared
longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-…

10.7554/eLife.41244.001 Aedes aegypti transmit pathogenic arboviruses while the mosquito
itself tolerates the infection. We examine a piRNA-based immunity that relies on the …

Before emergence of the SARS-CoV-2 B. 1.1. 529 (Omicron) variant, infectious SARS-CoV-2
was unlikely to be cultured at high cycle threshold (Ct) values. Based on this, low Ct values, …

Wastewater-based epidemiology (WBE) emerged during the coronavirus disease 2019 (COVID-19)
pandemic as a scalable and broadly applicable method for community-level …