[HTML][HTML] RORγt promotes Foxp3 expression by antagonizing the effector program in colonic regulatory T cells

S Bhaumik, ME Mickael, M Moran, M Spell… - The Journal of …, 2021 - journals.aai.org
RORγt is the master transcription factor for the Th17 cells. Paradoxically, in the intestine,
RORγt is coexpressed in peripherally induced regulatory T cells (pTregs) together with Foxp3, …

[HTML][HTML] Drugs modulating CD4+ T cells blood–brain barrier interaction in Alzheimer's disease

…, PCH Flournoy, AM Enciu, G Manda, ME Mickael - Pharmaceutics, 2020 - mdpi.com
The effect of Alzheimer’s disease (AD) medications on CD4+ T cells homing has not been
thoroughly investigated. CD4+ T cells could both exacerbate and reduce AD symptoms based …

The landscape of human mutually exclusive splicing

…, V Bansal, A Rajput, ME Mickael… - Molecular Systems …, 2017 - embopress.org
Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification
with pivotal roles in organismal development and diseases such as Timothy syndrome, …

[HTML][HTML] Interleukins and interleukin receptors evolutionary history and origin in relation to CD4+ T cell evolution

…, M Łazarczyk, M Sacharczuk, S Bhaumik, ME Mickael… - Genes, 2021 - mdpi.com
Understanding the evolution of interleukins and interleukin receptors is essential to control
the function of CD4+ T cells in various pathologies. Numerous aspects of CD4+ T cells’ …

[HTML][HTML] Paracellular and transcellular leukocytes diapedesis are divergent but interconnected evolutionary events

ME Mickael, N Kubick, P Klimovich, PH Flournoy… - Genes, 2021 - mdpi.com
Infiltration of the endothelial layer of the blood-brain barrier by leukocytes plays a critical role
in health and disease. When passing through the endothelial layer during the diapedesis …

Molecular evolution and functional divergence of the IgLON family

…, D Brösamle, ME Mickael - Evolutionary …, 2018 - journals.sagepub.com
IgLON family is a subgroup of cell adhesion molecules which is known to have diverse roles
in neuronal development. IgLONs are characterized by possessing 3 Ig-like C2 domains, …

[HTML][HTML] Investigation of the molecular evolution of Treg suppression mechanisms indicates a convergent origin

…, G Manda, M Sacharczuk, ME Mickael - Current Issues in …, 2023 - mdpi.com
Regulatory T cell (Treg) suppression of conventional T cells is a central mechanism that
ensures immune system homeostasis. The exact time point of Treg emergence is still disputed. …

RORγt-Expressing pathogenic CD4+ T cells cause brain inflammation during chronic colitis

ME Mickael, S Bhaumik, A Chakraborti… - The Journal of …, 2022 - journals.aai.org
Neurobehavioral disorders and brain abnormalities have been extensively reported in both
Crohn’s disease and ulcerative colitis patients. However, the mechanism causing …

What has single‐cell RNA sequencing revealed about microglial neuroimmunology?

…, P Klimovich, G Manda, ME Mickael - Immunity …, 2020 - Wiley Online Library
The use of single‐cell RNA sequencing (scRNA‐seq) in microglial research is increasing
rapidly. The basic workflow of this approach consists of isolating single cells, followed by …

[HTML][HTML] Digital technology applications in the management of adverse drug reactions: bibliometric analysis

O Litvinova, AWK Yeung, FP Hammerle, ME Mickael… - Pharmaceuticals, 2024 - mdpi.com
Adverse drug reactions continue to be not only one of the most urgent problems in clinical
medicine, but also a social problem. The aim of this study was a bibliometric analysis of the …