Senescence is a cellular phenotype present in health and disease, characterized by a stable
cell-cycle arrest and an inflammatory response called senescence-associated secretory …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility, …

SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome. …

Cellular senescence is a state of stable proliferative arrest triggered by damaging signals.
Senescent cells persist during aging and promote age-related pathologies via the pro-…

Cellular senescence is an important in vivo mechanism that prevents the propagation of
damaged cells. However, the precise mechanisms regulating senescence are not well …

Non-alcoholic fatty liver disease (NAFLD), an accumulation of intra-hepatic triglycerides that
is often considered the hepatic manifestation of insulin resistance, is the most common …

The extracellular fluid (ECF) is a crowded environment containing macromolecules that
determine its characteristic density, osmotic pressure, and viscosity, which greatly differ between …

Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC).
Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic …

Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition
in the liver, which are generally deteriorated during the aging process. MacroH2A1, a …

During this last decade, the development of prosenescence therapies has become an
attractive strategy as cellular senescence acts as a barrier against tumour progression. In this …