Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for
heart regeneration, though (inter)-relationships among reported cells remain obscure. Using …

Intercellular signaling mediated by Notch receptors is essential for proper cardiovascular
development and homeostasis. Notch regulates cell fate decisions that affect proliferation, …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

The elucidation of factors that activate the regeneration of the adult mammalian heart is of
major scientific and therapeutic importance. Here we found that epicardial cells contain a …

In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative
antagonist of basic helix–loop–helix transcription factors and proteins of the …

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …

Various studies have identified a critical role for Notch signaling in cardiovascular development.
In this and other systems, Notch receptors and ligands are expressed in regions that …

A and B, Comparison of ACE2 expression in human primary epithelial cells and ECs using
total RNA sequencing data from the ENCODE database shows low or absent expression in …

Although previous studies demonstrate that appropriate Notch signaling is required during
angiogenesis and in vascular homeostasis, the mechanisms by which Notch regulates …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial transcriptomics data …