The relationships between impaired cortical development and consequent malformations in
neurodevelopmental disorders, as well as the genes implicated in these processes, are not …

Transcription factors are expressed in a dynamic fashion both in time and space during brain
development, and exert their roles by activating a cascade of multiple target genes. This …

The formation and maturation of the human brain is regulated by highly coordinated
developmental events, such as neural cell proliferation, migration and differentiation. Any …

The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …

Optic nerve atrophy represents the most common form of hereditary optic neuropathies
leading to vision impairment. The recently described Bosch‐Boonstra‐Schaaf optic atrophy ( …

Increasing evidence suggests that neurodevelopmental alterations might contribute to increase
the susceptibility to develop neurodegenerative diseases. We investigate the occurrence …

The formation of functional cortical maps in the cerebral cortex results from a timely regulated
interaction between intrinsic genetic mechanisms and electrical activity. To understand …

Embryonic stem cells (ESCs) have been used extensively as in vitro models of neural
development and disease, with special efforts towards their conversion into forebrain progenitors …

Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder
referred to as the Bosch–Boonstra–Schaaf Optic Atrophy Syndrome. Although visual loss is …

Rn7SK‐mediated global transcriptional regulation, key function of this small nuclear RNA (snRNA),
is mediated by inhibition of the positive transcription elongation factor b (P‐TEFb). …