Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …

Human platelets contain microRNAs (miRNAs) and miRNA processing machinery, but their
contribution to platelet function remains incompletely understood. Here, we show that murine …

Thrombin is a potent platelet agonist that activates platelets and other cells of the cardiovascular
system by cleaving its G-protein-coupled receptors, protease-activated receptor 1 (PAR1…

Background Protease activated receptor 4 (PAR4) is a G protein coupled receptor (GPCR)
which is activated by proteolytic cleavage of its N-terminal exodomain. This generates a …

The article by Tourdot and colleagues appearing in this issue of Arteriosclerosis, Thrombosis,
and Vascular Biology expands on the previous work done by Edelstein et al. 5, 17 This …

Background Platelet adhesion is the critical process mediating stable thrombus formation.
Previous reports of cadherin‐6 on human platelets have demonstrated its role in platelet …

Background Platelet adhesion is the critical process mediating stable thrombus formation.
Previous reports of cadherin-6 on human platelets have demonstrated its role in platelet …

Protease activated receptors (PARs) are G-protein coupled receptors which are activated by
cleavage of their N-terminus by thrombin. This generates a tethered ligand which is then …

… PROTEASE ACTIVATED RECEPTOR 4 By MICHELE MARIE MUMAW Submitted in partial
fu … We hereby approve the thesis/dissertation of Michele Marie Mumaw candidate for the …

The regulation of hemostasis and thrombus formation is a tightly controlled event that has
catastrophic consequences when it is deregulated. One of the hallmarks of the thrombus is …