Radiation-induced lung fibrosis (RIF) is a delayed side-effect of chest radiotherapy, frequently
associated with macrophage infiltration. We aimed to characterise the role of pulmonary …

Ionizing radiation has historically been used to treat cancer by killing tumour cells, in particular
by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic agent has …

OBJECTIVE.: The primary aim of this study was to investigate the role of angiogenesis and
inflammatory cell response in cervical carcinogenesis. METHODS.: Formalin-fixed tissue …

Radiotherapy (RT) represents one of the main anticancer approaches for the treatment of
solid tumors. Beyond the expected direct effects of RT on tumor cells, evidence supporting the …

Purpose: Diffuse intrinsic pontine gliomas (DIPG) are the most severe pediatric brain tumors.
Although accepted as the standard therapeutic, radiotherapy is only efficient transiently and …

There is growing interest in the association of radiotherapy and immunotherapy for the
treatment of solid tumors. Here, we report an extremely effective combination of local irradiation (…

Epidermodysplasia verruciformis (EV) is a rare disease, characterized by cutaneous warts
and associated with a strong predisposition to β-genus human papillomavirus (HPV). Earlier …

Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF),
and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we …

Interferons (IFNs) are now known to exert a multitude of immunological functions on both
the innate and adaptive immunity. Given their pleiotropic effects on the immune system, it is …

Objective. To investigate the presence and clinical significance of autoantibodies against the
interferoninducible gene IFI16 in systemic sclerosis (SSc), systemic lupus erythematosus (…