During embryonic development, multipotent cardiovascular progenitor cells are specified
from early mesoderm. Using mouse ESCs in which gene expression can be temporally …

The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid
hormones, which are critical regulators of growth, development and metabolism in almost all …

Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate
cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme …

Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this
is strictly due to repression of proliferation remains a subject of debate. Here, we show that …

Recent studies support the existence of a common progenitor for the cardiac and endothelial
cell lineages, but the underlying transcriptional networks responsible for specification of …

To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an
inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9 expression in …

Mesp1 is regarded as the master regulator of cardiovascular development, initiating the
cardiac transcription factor cascade to direct the generation of cardiac mesoderm. To define the …

Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains
DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite …

Genetic modification is critically enabling for studies addressing specification and
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …

Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease
caused by genetic and biochemical defects of the dystrophin–glycoprotein complex. Here we …