Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Background Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability
and is two to seven times more common in male individuals than in female individuals. We …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

Complex traits, including migraine, often aggregate in families, but the underlying genetic
architecture behind this is not well understood. The aggregation could be explained by rare, …

Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…

The timing of puberty is highly variable and is associated with long-term health outcomes.
To date, understanding of the genetic control of puberty timing is based largely on studies in …

Hypersensitivity reactions to drugs are often unpredictable and can be life threatening,
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …

The genetic basis of earlobe attachment has been a matter of debate since the early 20 th
century, such that geneticists argue both for and against polygenic inheritance. Recent genetic …

Progress identifying the genetic determinants of personality has historically been slow, with
candidate gene studies and small-scale genome-wide association studies yielding few …

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains
unknown. In this study, we performed a phenome-wide association study and report that the …