Rationale: Accurate knowledge of the cellular composition of the heart is essential to fully
understand the changes that occur during pathogenesis and to devise strategies for tissue …

White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes
form throughout life, with the most marked expansion of the lineage occurring during the …

The adult mammalian heart possesses little regenerative potential following injury. Fibrosis
due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss …

Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM)
region of the midgestation embryo, but the cell type responsible for their emergence is …

Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute
myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. …

In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate,
proliferate and migrate in a process known as phenotypic modulation. However, the phenotype …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under
physiological conditions. In the adult heart, activated cardiac fibroblasts also participate in …

The basic helix-loop-helix (bHLH) family of transcription factors orchestrates cell-fate
specification, commitment and differentiation in multiple cell lineages during development. Here, …

We have generated a mouse line, MORE (Mox2Cre), which expresses the Cre recombinase
from the Mox2 locus. This locus drives expression of Cre throughout the epiblast following …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types co-…