User profiles for Michelle Dietzen
Michelle DietzenUniversity College London Cancer Institute Verified email at ucl.ac.uk Cited by 1194 |
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide 1 . Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients …
[HTML][HTML] The evolution of non-small cell lung cancer metastases in TRACERx
…, P Prymas, A Toncheva, S Hessey, M Dietzen… - Nature, 2023 - nature.com
Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …
Pervasive chromosomal instability and karyotype order in tumour evolution
Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …
[HTML][HTML] Genomic–transcriptomic evolution in lung cancer and metastasis
…, R Salgado, E Colliver, C Castignani, M Dietzen… - Nature, 2023 - nature.com
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy 1 . Here, using paired whole-exome and RNA sequencing data, …
and resistance to therapy 1 . Here, using paired whole-exome and RNA sequencing data, …
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
…, S Saghafinia, N Kanu, M Dietzen… - Nature medicine, 2023 - nature.com
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and …
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and …
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the
entire chromosome complement. However, despite its prevalence and prognostic relevance, …
entire chromosome complement. However, despite its prevalence and prognostic relevance, …
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
This study reveals the dynamics and drivers of APOBEC3 gene expression in preinvasive
disease and the exacerbation of cellular diversity by APOBEC3B through DNA replication …
disease and the exacerbation of cellular diversity by APOBEC3B through DNA replication …
[HTML][HTML] The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
…, J De Dios Palomino Villcas, N I. Vokes, M Dietzen… - Nature Genetics, 2024 - nature.com
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC)
enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung …
enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung …
[HTML][HTML] DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
Background The APOBEC3 family of cytidine deaminases mutate the cancer genome in a
range of cancer types. Although many studies have documented the downstream effects of …
range of cancer types. Although many studies have documented the downstream effects of …
[HTML][HTML] The subclonal architecture of metastatic breast cancer: results from a prospective community-based rapid autopsy program “CASCADE”
Background Understanding the cancer genome is seen as a key step in improving outcomes
for cancer patients. Genomic assays are emerging as a possible avenue to personalised …
for cancer patients. Genomic assays are emerging as a possible avenue to personalised …