Lung cancer is the leading cause of cancer-associated mortality worldwide 1 . Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients …

Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …

Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy 1 . Here, using paired whole-exome and RNA sequencing data, …

Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and …

Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the
entire chromosome complement. However, despite its prevalence and prognostic relevance, …

This study reveals the dynamics and drivers of APOBEC3 gene expression in preinvasive
disease and the exacerbation of cellular diversity by APOBEC3B through DNA replication …

In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC)
enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung …

Background The APOBEC3 family of cytidine deaminases mutate the cancer genome in a
range of cancer types. Although many studies have documented the downstream effects of …

Background Understanding the cancer genome is seen as a key step in improving outcomes
for cancer patients. Genomic assays are emerging as a possible avenue to personalised …