Adoptive transfer of genetically modified immune cells holds great promise for cancer
immunotherapy. CRISPR knockin targeting can improve cell therapies, but more high-throughput …

A hallmark of the immune system is the interplay among specialized cell types transitioning
between resting and stimulated states. The gene regulatory landscape of this dynamic …

The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …

Human regulatory T (T reg ) cells are essential for immune homeostasis. The transcription
factor FOXP3 maintains T reg cell identity, yet the complete set of key transcription factors that …

Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor
forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. We …

Infection triggers large-scale changes in the phenotype and function of T cells that are critical
for immune clearance, yet the gene regulatory mechanisms that control these changes are …

The changes in phenotype and function that characterize the differentiation of naïve T cells
to effector and memory states are underscored by large-scale, coordinated, and stable …

Numerous studies have focused on the molecular regulation of perforin (PFP) and granzyme
B (GZMB) expression by activated cytotoxic T lymphocytes (CTLs), but little is known about …

As a widely distributed parasitic nematode of ruminants, Haemonchus contortus has become
resistant to most anthelmintic classes, there has been a major demand for new compounds …

The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …