Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

…, Y Liu, MT Muldowney… - Proceedings of the …, 2012 - National Acad Sciences
Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT
pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and …

Suppressor of cytokine signaling 3 inhibits antiviral IFN-β signaling to enhance HIV-1 replication in macrophages

LN Akhtar, H Qin, MT Muldowney… - The Journal of …, 2010 - journals.aai.org
HIV-1 replication within macrophages of the CNS often results in cognitive and motor
impairment, which is known as HIV-associated dementia (HAD) in its most severe form. IFN-β …

A role for catalase-peroxidase large loop 2 revealed by deletion mutagenesis: control of active site water and ferric enzyme reactivity

SN Kudalkar, OJ Njuma, Y Li, M Muldowney… - Biochemistry, 2015 - ACS Publications
Catalase-peroxidases (KatGs), the only catalase-active members of their superfamily, all
possess a 35-residue interhelical loop called large loop 2 (LL2). It is essential for catalase …

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

…, M El-Banna, A Majumdar, DE Sleat, M Muldowney… - BioRxiv, 2019 - biorxiv.org
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid plaques surrounded
by microglia. In cell culture, microglia internalize fibrillar β-amyloid but do not degrade it …

Critical function of myeloid SOCS3 is in limiting the neuroinflammation of EAE (147.21)

H Qin, WI Yeh, P De Sarno, M Muldowney… - The Journal of …, 2011 - journals.aai.org
Macrophages and microglia are central players in the pathogenesis of inflammatory diseases
in the CNS, such as Multiple Sclerosis. SOCS proteins are critical feedback inhibitors of …

[BOOK][B] Examining the role of the lysosomal enzyme tripeptidyl-peptidase I in the degradation of fibrillar beta-amyloid

DL Cruz - 2013 - search.proquest.com
… Amitabha Majumdar for his collaboration and for training me on the Alzheimer's Disease
project; the laboratory technicians, Michelle Muldowney, Adina Buxbaum and Nikiya Asamoah, …

Informal carer support needs, facilitators and barriers in transitional care for older adults from hospital to home: A scoping review

…, M Lobchuk, A Muldowney… - Journal of Clinical …, 2023 - Wiley Online Library
Aim To synthesise evidence about informal carers' (carers) experience of their support
needs, facilitators and barriers regarding transitional care of older adults with multimorbidity. …

[PDF][PDF] Perioperative Outcomes and Surgical Case Volume in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Observational Study From the Pediatric …

BL Muldowney, JL Martinez, F Chiao, PA Stricker - 2018 - academia.edu
BACKGROUND: Complex cranial vault reconstruction (CCVR) performed to treat
craniosynostosis can be associated with significant blood loss, transfusion, and perioperative …

[PDF][PDF] Outward Beauty, Hidden Wrath: An Exploration of the Drikung Kagyü Dharma Protectress Achi Chökyi Drölma

KK Muldowney - 2011 - diginole.lib.fsu.edu
… The members of the committee approve the thesis of Kristen Kail Muldowney defended on …
of Buddhism,” in Du Dunhuang au Japon: Études chinoises et bouddhiques offertes à Michel

'A world of its own': recollections of women workers in Guinness's brewery in the 1940s

M Muldowney - Saothar, 1998 - JSTOR
During the 1940s, despite the reduction in many areas of work occasioned by the Emergency,
the Guinness brewery in St James's Gate provided secure employment for a wide range of …