Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …

To maintain homeostasis under variable nutrient conditions, cells rapidly and robustly
respond to fluctuations through adaptable signaling networks. Evidence suggests that the O-linked …

Transient and low-affinity interactions among macromolecules underlie many physiological
events. Often, these interactions are difficult to study because they are not maintained when …

O-linked β-N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification
found on hundreds of nuclear and cytoplasmic proteins in higher eukaryotes. Despite its …

Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential
and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose …

10.7554/eLife.09545.001 Cholera toxin (CT) enters and intoxicates host cells after binding
cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought …

Proteostasis is essential in the mammalian brain where post‐mitotic cells must function for
decades to maintain synaptic contacts and memory. The brain is dependent on glucose and …

Transient interactions among glycoconjugates underlie developmental, immunological and
metastatic recognition. Glycan-mediated interactions have low binding affinities and rapid …

Terminal sialic acid residues often mediate the interactions of cell surface glycoconjugates.
Sialic acid-dependent interactions typically exhibit rapid dissociation rates, precluding the …

An important frontier in glycoproteomics is the discovery of proteins with post-translational
glycan modifications. The first step in glycoprotein identification is the isolation of glycosylated …