Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is
known regarding the biology underlying this symptom. We conducted a genome-wide …

Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few
genetic variants have been identified for osteoarthritis, which is partly due to large phenotype …

Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of
disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; …

Objective To estimate the dynamic causal effects of depressive symptoms on osteoarthritis (
OA ) knee pain. Methods Marginal structural models were used to examine dynamic …

Objective A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large
numbers of individuals with standardized radiographic evaluations for OA. To address this …

Knee pain is one of the most common musculoskeletal complaints that brings people to
medical attention. Approximately 50% of individuals over the age of 50 report an experience of …

Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target
of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods …

Background Despite recent advances in the understanding of the genetic architecture of
osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part …

Depressive symptoms are associated with increases in pain and functional limitations in
knee osteoarthritis (OA). The aim was to determine whether depressive symptoms are also …

Osteoarthritis (OA) risk is widely recognized to be heritable but few loci have been identified.
Observational studies have identified higher systemic bone mineral density (BMD) to be …