<p id="p001">We assessed the feasibility of transplanting a sheet of retinal pigment epithelial
(RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

It has long been believed that the retina of mature mammals is incapable of regeneration. In
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …

We previously reported the differentiation of mouse embryonic stem (ES) cells into retinal
progenitors. However, these progenitors rarely differentiate into photoreceptors unless they are …

Age-related macular degeneration (AMD) causes severe visual impairment due in part to
age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that …

Stem cell-based therapy for retinal degeneration is transitioning from the research stage to
the clinical stage and is being developed as a treatment across the globe. In clinical studies …

Retinal pigment epithelial (RPE) cells have several functions, including support of the neural
retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly …

Regeneration in the mammalian CNS is severely limited. Unlike in the chick, current models
hold that retinal neurons are never regenerated. Previously we demonstrated that, in the …

In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived
3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner …

Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to
accumulating evidence of transplantation efficacy from animal studies and development of …