The mechanisms underlying olanzapine-induced weight gain have not yet been fully
elucidated. To examine the effects of long-term treatment with olanzapine on different aspects of …

Objectives: Rats subjected to a free-choice high-fat high-sugar (fcHFHS) diet persistently
overeat, exhibit increased food-motivated behavior and become overtly obese. Conversely, …

We here describe a technique to transiently activate specific neural pathways in vivo. It
comprises the combined use of a CRE-recombinase expressing canine adenovirus-2 (CAV-2) …

Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia
nervosa that include food restriction-induced hyperlocomotion, we found that plasma …

Hyperactivity is a core symptom in various psychiatric disorders, including attention-deficit/hyperactivity
disorder, schizophrenia, bipolar disorders, and anorexia nervosa. Although …

Food anticipatory activity (FAA) is displayed in rats when access to food is restricted to a
specific time frame of their circadian phase, a behavior thought to reflect both hunger and the …

Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and
negatively impacts on disease outcome. Using an animal model that mimics features of AN …

Hyperdopaminergic states in mental disorders are associated with disruptive deficits in
decision making. However, the precise contribution of topographically distinct mesencephalic …

Deficits in impulse control and attention are prominent in the symptomatology of mental
disorders such as attention deficit hyperactivity disorder (ADHD), substance addiction, …

Motivational deficits are a key symptom in multiple psychiatric disorders, including major
depressive disorder, schizophrenia and addiction. A likely neural substrate for these …