Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are …

Schwanniomyces occidentalis invertase is an extracellular enzyme that hydrolizes sucrose
and releases β-fructose from various oligosaccharides and essential storage fructan …

β-Fructofuranosidases are powerful tools in industrial biotechnology. We have characterized
an extracellular β-fructofuranosidase from the yeast Schwanniomyces occidentalis. The …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree of …

Type 1 diabetes is an autoimmune disease with rising incidence in high-income countries.
Genetic and environmental predisposing factors contribute to the etiology of the disease, …

The major histocompatibility complex of class II (MHCII) immunopeptidome represents the
repertoire of antigenic peptides with the potential to activate CD4 + T cells. An understanding …

Schwanniomyces occidentalis β-fructofuranosidase (Ffase) is a GH32 dimeric enzyme that
releases fructose from the nonreducing end of various oligosaccharides and essential …

… Miguel Álvaro-Benito is a senior postdoctoral researcher in the group of Christian Freund
at the department of Biochemistry of the Freie Universität Berlin. He studied Biochemistry and …

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-known
immunological concept in vertebrates, yet the conformational dynamics of antigen …

Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The
reversible nature of this modification makes it a prime candidate as a mechanism for …