Epigenetic genome modifications are thought to be important for specifying the lineage and
developmental stage of cells within a multicellular organism. Here, we show that the …

Abstract Changes in phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase
II (RNAP) are associated with transcription initiation, elongation and termination 1 , 2 , 3 …

At the time of fertilization, the paternal genome lacks the typical configuration and marks
characteristic of pericentric heterochromatin. It is thus essential to understand the dynamics of …

Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In
embryonic stem (ES) cells many genes that regulate subsequent stages in development are …

Sex chromosome dosage compensation is essential in most metazoans, but the developmental
timing and underlying mechanisms vary significantly, even among placental mammals. …

Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental
biology and regenerative medicine, notably because they circumvent the use of cells of …

The equalization of pericentric heterochromatin from distinct parental origins following
fertilization is essential for genome function and development. The recent implication of …

Polycomb group (PcG) proteins play an important role in the control of developmental gene
expression in higher organisms. In mammalian systems, PcG proteins participate in the …

Background Alveolar soft part sarcomas (ASPS) are generally chemo‐ and radio‐resistant
mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical …

The Polycomb group of proteins forms at least two distinct complexes designated the
Polycomb repressive complex-1 (PRC1) and PRC2. These complexes cooperate to mediate …