The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular
communication, and potential as drug delivery vehicles. Here we demonstrate a role for the …

10.7554/eLife.21374.001 cAMP/PKA signalling is compartmentalised with tight spatial and
temporal control of signal propagation underpinning specificity of response. The cAMP-…

Cyclic AMP (cAMP) activates protein kinase A (PKA) but also the guanine nucleotide exchange
factor ‘exchange protein directly activated by cAMP’ (EPAC1; also known as RAPGEF3). …

Background We hypothesized that the clinical course of venous thromboembolism in patients
with active cancer may differ according to the specificities of primary tumor site. Aim and …

Programmed degradation of mitochondria by mitophagy, an essential process to maintain
mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory …

Importance Insufficient data exist about the clinical presentation, short-term, and long-term
outcomes of patients with isolated distal deep vein thrombosis (IDDVT), that is, thrombosis in …

Fluorescence resonance energy transfer (FRET)-based sensors for 3′–5′cyclic adenosine
monophosphate (cAMP) and protein kinase A (PKA) allow real-time imaging of cAMP …

Aims Little is known about the prognosis of patients with massive pulmonary embolism (PE)
and its risk of recurrent venous thromboembolism (VTE) compared with non‐massive PE, …

Background A comprehensive evaluation of temporal trends in the treatment of patients who
have DVT may assist with identification of modifiable factors that contribute to short-term …