The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses
a severe threat to humanity and demands the redirection of scientific efforts and criteria to …

SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the public
health. The variants increased challenges to vaccines, thus necessitating for development of …

Background Benralizumab is a humanised, anti-interleukin 5 receptor α monoclonal
antibody that directly and rapidly depletes eosinophils, reduces asthma exacerbations, and …

Polyproline II (PPII) helices play vital roles in biochemical recognition events and structures
like collagen and form part of the conformational landscapes of intrinsically disordered …

Background Clostridium difficile, a major cause of nosocomial and antibiotic-associated
diarrhea, carries a significant disease and cost burden. This study aimed to select an optimal …

The SARS-CoV-2 Nsp8 protein is a critical component of the RNA replicase, as its N-terminal
domain (NTD) anchors Nsp12, the RNA, and Nsp13. Whereas its C-terminal domain (CTD) …

The human pathogen Streptococcus pneumoniae is decorated with a special class of
surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine (PCho) …

Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction and
contribute to a significant number of incurable human diseases. Scarce structural insights …

Background This trial assessed the effect of tolvaptan on cognition, gait, and postural stability
in adult patients with mild to moderate asymptomatic hyponatremia. Study Design Phase 3b…

Importance Intense interest exists in novel ω-3 formulations with high bioavailability to reduce
blood triglyceride (TG) levels. Objective To determine the phase 3 efficacy and safety of a …