Active colloidal suspensions exhibit polar order under gravity
M Enculescu, H Stark - Physical review letters, 2011 - APS
Recently, the steady sedimentation profile of a dilute suspension of chemically powered
colloids was studied experimentally [J. Palacci et al., Phys. Rev. Lett. 105, 088304 (2010)]. It …
colloids was studied experimentally [J. Palacci et al., Phys. Rev. Lett. 105, 088304 (2010)]. It …
[PDF][PDF] Actin filament elasticity and retrograde flow shape the force-velocity relation of motile cells
J Zimmermann, C Brunner, M Enculescu, M Goegler… - Biophysical journal, 2012 - cell.com
Cells migrate through a crowded environment during processes such as metastasis or
wound healing, and must generate and withstand substantial forces. The cellular motility …
wound healing, and must generate and withstand substantial forces. The cellular motility …
[HTML][HTML] Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
S Braun, M Enculescu, ST Setty… - Nature …, 2018 - nature.com
Mutations causing aberrant splicing are frequently implicated in human diseases including
cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to …
cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to …
[HTML][HTML] Modelling systemic iron regulation during dietary iron overload and acute inflammation: role of hepcidin-independent mechanisms
M Enculescu, C Metzendorf, R Sparla… - PLoS computational …, 2017 - journals.plos.org
Systemic iron levels must be maintained in physiological concentrations to prevent diseases
associated with iron deficiency or iron overload. A key role in this process plays ferroportin, …
associated with iron deficiency or iron overload. A key role in this process plays ferroportin, …
[HTML][HTML] High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
M Cortés-López, L Schulz, M Enculescu… - Nature …, 2022 - nature.com
Following CART-19 immunotherapy for B-cell acute lymphoblastic leukaemia (B-ALL),
many patients relapse due to loss of the cognate CD19 epitope. Since epitope loss can be …
many patients relapse due to loss of the cognate CD19 epitope. Since epitope loss can be …
[PDF][PDF] Modeling of protrusion phenotypes driven by the actin-membrane interaction
We propose a mathematical model for simulating the leading-edge dynamics of a migrating
cell from the interplay among elastic properties, architecture of the actin cytoskeleton, and …
cell from the interplay among elastic properties, architecture of the actin cytoskeleton, and …
Leading-edge–gel coupling in lamellipodium motion
J Zimmermann, M Enculescu, M Falcke - Physical Review E, 2010 - APS
We present a model for actin-based motility that combines the dynamics of the semiflexible
region at the leading edge of the lamellipodium with actomyosin gel properties in the bulk …
region at the leading edge of the lamellipodium with actomyosin gel properties in the bulk …
[HTML][HTML] Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
T Horn, A Gosliga, C Li, M Enculescu… - npj Systems Biology and …, 2023 - nature.com
Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases
the complexity of gene expression programs, but is frequently altered in disease. Previous …
the complexity of gene expression programs, but is frequently altered in disease. Previous …
Dynamic regimes and bifurcations in a model of actin-based motility
Propulsion by actin polymerization is widely used in cell motility. Here, we investigate a
model of the brush range of an actin gel close to a propelled object, describing the force …
model of the brush range of an actin gel close to a propelled object, describing the force …
Membrane waves driven by forces from actin filaments
Membrane waves propagating along the cell circumference in a top down view have been
observed with several eukaryotic cells (Döbereiner et al 2006 Phys. Rev. Lett. 97 10; …
observed with several eukaryotic cells (Döbereiner et al 2006 Phys. Rev. Lett. 97 10; …