User profiles for Mihnea R. Mangalea

Mihnea R Mangalea, Ph.D.

Centers for Disease Control and Prevention
Verified email at cdc.gov
Cited by 607

Fitness trade-offs resulting from bacteriophage resistance potentiate synergistic antibacterial strategies

MR Mangalea, BA Duerkop - Infection and immunity, 2020 - Am Soc Microbiol
Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance, …

The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD

RW McKee, MR Mangalea, EB Purcell… - Journal of …, 2013 - Am Soc Microbiol
The Gram-positive obligate anaerobe Clostridium difficile causes potentially fatal intestinal
diseases. How this organism regulates virulence gene expression is poorly understood. In …

[PDF][PDF] Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

MR Mangalea, D Paez-Espino, K Kieft, A Chatterjee… - Cell host & …, 2021 - cell.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals
by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the …

[HTML][HTML] Nitrate sensing and metabolism inhibit biofilm formation in the opportunistic pathogen Burkholderia pseudomallei by reducing the intracellular concentration …

MR Mangalea, BA Plumley, BR Borlee - Frontiers in microbiology, 2017 - frontiersin.org
The opportunistic pathogen Burkholderia pseudomallei is a saprophytic bacterium and the
causative agent of melioidosis, an emerging infectious disease associated with high …

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

…, A Chatterjee, J Espinosa, MR Mangalea… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Enterococcus faecium , a commensal of the human intestine, has emerged as a hospital-adapted,
multidrug-resistant (MDR) pathogen. Bacteriophages (phages), natural predators of …

[HTML][HTML] The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

MR Mangalea, BR Borlee - Scientific reports, 2022 - nature.com
Burkholderia pseudomallei is a saprophytic bacterium endemic throughout the tropics causing
severe disease in humans and animals. Environmental signals such as the accumulation …

Model of chronic equine endometritis involving a Pseudomonas aeruginosa biofilm

…, KE Glapa, KH Martin, MR Mangalea… - Infection and …, 2017 - Am Soc Microbiol
Bacteria in a biofilm community have increased tolerance to antimicrobial therapy. To
characterize the role of biofilms in equine endometritis, six mares were inoculated with lux-…

[PDF][PDF] A field protocol for the capture and release of callitrichids

…, S Cassalett, E Maciag, MR Mangalea… - Neotropical …, 2015 - primate-sg.org
While primate trapping is a widely used field methodology, there are substantial health, safety
and social risks to handling wild primates, necessitating sharing of best-practice methods …

[HTML][HTML] Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene …

…, KH Martin, N Somprasong, MR Mangalea… - PLoS neglected …, 2017 - journals.plos.org
Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health
threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. …

Haloviruses of Great Salt Lake: a model for understanding viral diversity

BK Baxter, MR Mangalea, S Willcox, S Sabet… - … : current research and …, 2011 - Springer
Our understanding of halovirus diversity is limited since viral isolation is traditionally based
on the ability to culture the host species. Here, we review current knowledge of viruses in …