User profiles for Mihnea R. Mangalea
Mihnea R Mangalea, Ph.D.Centers for Disease Control and Prevention Verified email at cdc.gov Cited by 607 |
Fitness trade-offs resulting from bacteriophage resistance potentiate synergistic antibacterial strategies
MR Mangalea, BA Duerkop - Infection and immunity, 2020 - Am Soc Microbiol
Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance, …
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance, …
The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD
The Gram-positive obligate anaerobe Clostridium difficile causes potentially fatal intestinal
diseases. How this organism regulates virulence gene expression is poorly understood. In …
diseases. How this organism regulates virulence gene expression is poorly understood. In …
[PDF][PDF] Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential
Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals
by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the …
by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the …
[HTML][HTML] Nitrate sensing and metabolism inhibit biofilm formation in the opportunistic pathogen Burkholderia pseudomallei by reducing the intracellular concentration …
MR Mangalea, BA Plumley, BR Borlee - Frontiers in microbiology, 2017 - frontiersin.org
The opportunistic pathogen Burkholderia pseudomallei is a saprophytic bacterium and the
causative agent of melioidosis, an emerging infectious disease associated with high …
causative agent of melioidosis, an emerging infectious disease associated with high …
Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium
Enterococcus faecium , a commensal of the human intestine, has emerged as a hospital-adapted,
multidrug-resistant (MDR) pathogen. Bacteriophages (phages), natural predators of …
multidrug-resistant (MDR) pathogen. Bacteriophages (phages), natural predators of …
[HTML][HTML] The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei
MR Mangalea, BR Borlee - Scientific reports, 2022 - nature.com
Burkholderia pseudomallei is a saprophytic bacterium endemic throughout the tropics causing
severe disease in humans and animals. Environmental signals such as the accumulation …
severe disease in humans and animals. Environmental signals such as the accumulation …
Model of chronic equine endometritis involving a Pseudomonas aeruginosa biofilm
…, KE Glapa, KH Martin, MR Mangalea… - Infection and …, 2017 - Am Soc Microbiol
Bacteria in a biofilm community have increased tolerance to antimicrobial therapy. To
characterize the role of biofilms in equine endometritis, six mares were inoculated with lux-…
characterize the role of biofilms in equine endometritis, six mares were inoculated with lux-…
[PDF][PDF] A field protocol for the capture and release of callitrichids
…, S Cassalett, E Maciag, MR Mangalea… - Neotropical …, 2015 - primate-sg.org
While primate trapping is a widely used field methodology, there are substantial health, safety
and social risks to handling wild primates, necessitating sharing of best-practice methods …
and social risks to handling wild primates, necessitating sharing of best-practice methods …
[HTML][HTML] Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene …
…, KH Martin, N Somprasong, MR Mangalea… - PLoS neglected …, 2017 - journals.plos.org
Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health
threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. …
threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. …
Haloviruses of Great Salt Lake: a model for understanding viral diversity
Our understanding of halovirus diversity is limited since viral isolation is traditionally based
on the ability to culture the host species. Here, we review current knowledge of viruses in …
on the ability to culture the host species. Here, we review current knowledge of viruses in …