[HTML][HTML] Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML

M Caplan, KJ Wittorf, KK Weber, SA Swenson… - Leukemia, 2022 - nature.com
Acute myeloid leukemia (AML) is a devastating cancer affecting the hematopoietic system.
Previous research has relied on RNA sequencing and microarray techniques to study the …

[HTML][HTML] Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemia

…, SA Swenson, H Vahle, KJ Wittorf, M Caplan… - Cancers, 2019 - mdpi.com
The hematopoietic system is maintained throughout life by stem cells that are capable of
differentiating into all hematopoietic lineages. An intimate balance between self-renewal, …

Ubiquitin E3 ligase FBXO9 regulates pluripotency by targeting DPPA5 for ubiquitylation and degradation

…, C Bea Winship, R Willow Hynes-Smith, M Caplan… - Stem Cells, 2024 - academic.oup.com
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have unique
characteristics where they can both contribute to all three germ layers in vivo and self-renewal …

Regulation of GPCR‐induced Hippo pathway signaling by ARRDC3 in breast carcinoma

M Caplan, JA Trejo - The FASEB Journal, 2022 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are a large and diverse family of cell surface receptors
implicated in cancer progression. In particular, overexpression of the GPCR protease‐…

Identifying protein expression changes in acute myeloid leukemia

M Caplan, W Hynes-Smith, S Swenson… - The FASEB …, 2020 - Wiley Online Library
Acute myeloid leukemia (AML) is a devastating cancer affecting the hematopoietic system. It
is characterized by infiltration of abnormal proliferating immature myeloid cells originating in …

HIV Suppresses Cervical Neutrophil Infiltration in Women with Normal or Abnormal Pap Smears

M Caplan, PC Angeletti, D Loy, K Samwel, D Gonzalez… - 2018 - digitalcommons.unl.edu
Human immunodeficiency virus (HIV) infection of CD4+ T cells results in a weakened
immune system due to decreased white blood cells, particularly multi-lobed neutrophils (…

The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis

R Hynes-Smith - 2019 - digitalcommons.unmc.edu
… Samantha Swenson, Karli Wittorf, Tyler Gilbreath, and Mika Caplan. Thank you for sharing
your knowledge with me and helping me at times when I was unable to complete projects, …

[HTML][HTML] mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft

D Magda, P Lecane, J Prescott, P Thiemann, X Ma… - BMC genomics, 2008 - Springer
Background Interactions between the gene products encoded by the mitochondrial and
nuclear genomes play critical roles in eukaryotic cellular function. However, the effects …

The cytoskeleton‐associated TCR ζ chain is constitutively phosphorylated in the absence of an active p56lck form

S Caplan, O Almogi‐Hazan, A Ezernitchi… - European Journal of …, 2001 - Wiley Online Library
… We also thank Mika Caplan for her efforts on our behalf. We gratefully acknowledge the
support of the Society for Research Associates of the Lautenberg Center, the United States-…

Neutrophil Infiltration into the Cervical Compartment is Suppressed by HIV Infection

M Maschka - 2020 - digitalcommons.unl.edu
Human Papillomavirus (HPV), is a small circular dsDNA virus with at least 200 different
genotypes; each genotype is identified by at least 10% difference at the DNA level in the L1 …