Medicine and healthcare are undergoing profound changes. Whole-genome sequencing
and high-resolution imaging technologies are key drivers of this rapid and crucial …

Personalized medicine requires the integration and processing of vast amounts of data. Here,
we propose a solution to this challenge that is based on constructing Digital Twins. These …

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World
Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic …

Reported COVID‐19 deaths in Germany are relatively low as compared to many European
countries. Among the several explanations proposed, an early and large testing of the …

The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch
a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in …

Many common diseases, such as asthma, diabetes or obesity, involve altered interactions
between thousands of genes. High-throughput techniques (omics) allow identification of such …

Background The DNA methylation profiles of mammalian cell lines differ from those of the
primary tissues from which they were derived, exhibiting increasing divergence from the in vivo …

Urine and serum interleukin (IL)-6 and IL-8responseswere higher in children with febrile urinary
tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate …

Background Previous studies of network properties of human disease genes have mainly
focused on monogenic diseases or cancers and have suffered from discovery bias. Here we …

… Benson, Clinical implications of omics and systems medicine: Focus on predictive and
individualized treatment. J. Intern. … Benson, A validated gene regulatory network and …