Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease afflicting the voluntary
motor system. More than 100 different mutations in the ubiquitously expressed enzyme …

Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations
in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (…

More than 100 point mutations of the superoxide scavenger Cu/Zn superoxide dismutase (SOD;
EC ) have been associated with the neurodegenerative disease amyotrophic lateral …

The molecular mechanism by which the homodimeric enzyme Cu/Zn superoxide dismutase
(SOD) causes neural damage in amytrophic lateral sclerosis is yet poorly understood. A …

Infection by the human bacterial pathogen Listeria monocytogenes is mainly controlled by
the positive regulatory factor A (PrfA), a member of the Crp/Fnr family of transcriptional …

Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase
activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins …

MAML1 is a transcriptional coregulator originally identified as a Notch coactivator. MAML1
is also reported to interact with other coregulator proteins, such as CDK8 and p300, to …

Earlier studies demonstrated the involvement of the p300 histone acetyltransferase in Notch
signaling but the precise mechanisms by which p300 might modulate Notch function …

Glycogen synthase kinase 3β (GSK3β) is involved in several cellular signaling systems
through regulation of the activity of diverse transcription factors such as Notch, p53 and β-catenin…

To fully understand the function of the Cu- and Zn-containing superoxide dismutases in
normal and disordered cells, it is essential to study protein variants with full metal contents. We …