Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to
the EGF receptor (EGFR) extracellular region, comprising domains I–IV, with the resultant …

Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2,
and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively. …

Pombe Cdc15 homology (PCH) proteins play an important role in a variety of actin-based
processes, including clathrin-mediated endocytosis (CME). The defining feature of the PCH …

The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate more
than half of the human kinome. However, both the mechanism by which these chaperones …

Two major structural genomics projects exist in Japan. The oldest, the RIKEN Structural
Genomics Initiative, has two major goals: to determine bacterial, mammalian, and plant protein …

A suppressor tRNA Tyr and mutant tyrosyl‐tRNA synthetase (TyrRS) pair was developed to
incorporate 3‐iodo‐l‐tyrosine into proteins in mammalian cells. First, the Escherichia coli …

SQUAMOSA promoter binding proteins (SBPs) form a major family of plant-specific transcription
factors related to flower development. Although SBPs are heterogeneous in primary …

To prevent neoplasia, cells of multicellular organisms activate cellular disposal programs
such as apoptosis in response to deregulated oncogene expression, making the suppression …

ErbB tyrosine kinase receptors mediate mitogenic signal cascade by binding a variety of
ligands and recruiting the different cassettes of adaptor proteins. In the present study, we …

To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape
to the given structure of the extracellular matrix and follow the path of least resistance. It is …